Facts About Statin Drugs
Statin drugs, also known as HMG-CoA reductase inhibitors, are one of the most common pharmaceutical drugs prescribed to patients. They are a class of drugs that are used to reduce the levels of plasma cholesterol. Results from clinical research has shown that these drugs have a variety of benefits such as lowering cholesterol and reducing heart attack risks of patients with diagnosed heart disease.
Types of Statin Drugs
Statin drugs are typically separated into two groups: synthetic and fermentation-derived. The synthetic drugs include: atorvastin (commonly known as Lipitor and Torvast), fluvastatin (commonly known as Lescol), Cerivastatin (commonly known as Lipobay), pitavastatin (commonly known as Pitava and Livalo), and rosuvastatin (commonly known as Crestor. The fermentation-derived include: lovastatin (commonly known as Mevacor, Altoprev, and Altocor), pravastatin (commonly known as Lipostat, Selektine, and Pravachol), and simvastain (commonly known as Zocor and Lipex). Many of these drugs are often available in generic forms.
How the Drugs Work
These drugs work to improve the levels of cholesterol in the blood by inhibiting HMG-CoA reductase, which is a liver enzyme that aids in making cholesterol. By inhibiting the HMG-CoA reductase, these drugs block the pathway that is needed to synthesize the cholesterol in the liver. The drugs assist in significantly reducing the “bad” cholesterol, known as LDL. They also help increase “good” cholesterol called HDL, and moderately reduce the levels of triglycerides.
Besides lowering cholesterol, statin drugs have a variety of other benefits, especially for individuals that have heart disease. These benefits include: improving overall function of the vascular system, decreasing blood clot formation, reducing C-reactive protein (CRP) levels, reducing the size of plaques in the arteries, reducing Drogen online kaufen inflammation, and stabilizing plaques. Recent research has also shown that these type of drugs help prevent Alzheimer’s disease, reduce the risk of stroke, reduce blood pressure, reduce the incidence of certain cancers, and prevent cataracts.
These drugs are usually regarded as well-tolerated drugs. The most common side effects of these drugs are gastrointestinal issues such as upset stomach, gas, and nausea. Less common effects include rash, dizziness, headache, and disturbances in sleep. Reports have indicated that these drugs also cause liver enzyme increases in approximately 1 out of 100 patients. There is not much evidence to indicate statin drugs cause serious or permanent damage to the liver. These drugs can also cause a muscle disorder in about 1 in 1,000 patients that results in occasional pain and weakness in the muscles. A more serious, but rare reaction includes myopathy and myositis. Some reports have shown that these type of drugs can occasionally cause cognitive issues such as difficulty concentrating and some reports indicate a slight increase risk in developing cancer. Experts do not widely accept these indications.